DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs
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چکیده
منابع مشابه
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting the existence of alternative DGCR8 complex(es) with other nucleases to process a variety of c...
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چکیده ندارد.
The Sm Complex Is Required for the Processing of Non-Coding RNAs by the Exosome
A key question in the field of RNA regulation is how some exosome substrates, such as spliceosomal snRNAs and telomerase RNA, evade degradation and are processed into stable, functional RNA molecules. Typical feature of these non-coding RNAs is presence of the Sm complex at the 3'end of the mature RNA molecule. Here, we report that in Saccharomyces cerevisiae presence of intact Sm binding site ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2015
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2015.11.011